Miguel Díaz-Canel told crowds in Havana the US is attempting to break down Cuba’s political system.
He declared America aims for complete control over Cuba.
Díaz-Canel described American policies a type of political genocide during July 26 events.
He warned this is a danger to the country's right to govern.
Raúl Castro was absent from the largest rally.
Tensions are elevated as a result of sanctions and US political pressure.