Recent research indicates that individuals suffering from insomnia who take melatonin supplements for over a year may face an increased risk of heart failure compared to those who do not use this sleep aid.
The study found that long-term melatonin users were more likely to be diagnosed with heart failure, require hospitalization for the condition, or experience death from any cause. These findings were presented at the American Heart Association’s Scientific Sessions 2025 in New Orleans.
It is important to note that this study is preliminary and has not been published in a peer-reviewed journal.
The researchers emphasized that their findings do not prove a direct cause-and-effect link between melatonin use and heart failure risk. However, they suggested that the results highlight potential safety issues regarding prolonged melatonin consumption and call for further investigation into its cardiovascular effects.
Many melatonin supplements are available over-the-counter without a prescription and are not regulated. This allows people to use them without medical supervision, raising concerns about their assumed harmlessness.
“Melatonin supplements may not be as harmless as commonly assumed.”
Author's summary: Long-term melatonin use in people with insomnia may increase the risk of heart failure, suggesting the need for more research into its safety and regulated medical guidance.