NFL Picks and Predictions for Week 6
The NFL season continues with a highly-anticipated slate of games in Week 6. Here are 3 plus-money bets to consider before kickoff.
By Spenser Davis, Published: Oct 12, 2025 · 8:30 AM EDT
Previous Week's Performance
Last week's NFL bold predictions went 2-1, resulting in a gain of +1.17 units overall. Since the start of Week 3, picks in this story are up 2.16 units.
This Week's Predictions
Here are 3 bold predictions for Week 6:
- Fading the Colts offense, despite their current average of 3.39 points per drive, which would be the highest this century if maintained all season.
Fading the Colts offense is perhaps not the wisest choice, but I think there’s a case for doing so here.
Author's summary: NFL Week 6 picks and predictions.