Indiana vs. Penn State Prediction, Odds, and Picks — November 8, 2025
The upcoming matchup between the Indiana Hoosiers and Penn State Nittany Lions promises to be an intriguing Big Ten clash. The No. 2-ranked Indiana Hoosiers (9-0) arrive as 14.5-point favorites on the road at West Shore Home Field at Beaver Stadium against the Penn State Nittany Lions (3-5).
Game Overview
- Date: Saturday, November 8, 2025
- Location: West Shore Home Field at Beaver Stadium
- Spread: Indiana -14.5
- Over/Under: 48.5 points
Team Performance
Indiana comes off a dominant 55–10 win over the Maryland Terrapins, maintaining its undefeated record. Penn State, meanwhile, suffered a 38–14 defeat to Ohio State in its last outing.
Defensive Rankings
- Indiana ranks 17th nationally in pass defense.
- Penn State ranks 14th in defending the pass.
Betting and Data Insight
Predictions and odds are generated by the Data Skrive betting model, using data supplied by Sportradar.
This analysis and predictive content were created by FOX Sports with the support of automated tools and official data partners.
Additional Information
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Author Summary
Indiana enters as the road favorite against Penn State with a strong defense and perfect record, while Data Skrive’s betting model projects another decisive win for the Hoosiers.